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San Francisco detective Ray Nettles (TOM SIZEMORE) and his partner Fuzzy (NAS) find themselves confronting one of the most dangerous terrorist gangs the city has ever known. When one of the terrorists, beautiful scientist Claire Manning (JAIME PRESSLY), is arrested, the terrorist leader Swan (DENNIS HOPPER) threatens to detonate bombs across the city in order to secure her release.
Faced with the potential carnage, Nettles turns to Bomb Squad expert Frank Glass (STEVEN SEAGAL) for help. Ticker hurtles to an explosive conclusion as Glass and Nettles must capture and "detonate" Claire before she goes nuclear and takes out the entire city of San Francisco.